Antimicrobial resistance (AMR) poses a significant threat to global public health, driven by various environmental, clinical, and socio-economic factors. This study aims to elucidate the impact of environmental variables on the emergence and spread of AMR across diverse geographical regions. Using a combination of genomic, ecological, and socio-economic data, we conducted a comprehensive analysis to identify key factors contributing to AMR proliferation. Our methods included high-throughput sequencing of microbial communities from different ecosystems, alongside data integration from public health and environmental databases. We found that regions with higher pollution levels and greater antibiotic consumption exhibited increased rates of resistant strains. Additionally, our research highlights the role of climate change and urbanization in accelerating AMR development. Our findings underscore the necessity for interdisciplinary approaches in combating AMR, integrating public health policies with environmental conservation efforts. The study concludes that proactive and coordinated global strategies are required to mitigate the environmental contributors to AMR, emphasizing the importance of sustainable practices in curbing this growing health concern.